EC Number   |
General Information  |
Reference |
|---|
   3.4.21.9 | more |
enterokinase shows no strict cleavage site specificity because of sporadic cleavage at other sites, which consist of acidic and basic residues |
717409 |
| 3.4.21.9 | more |
improved efficiency of fusion proteins cleavage by enteropeptidase by substitution of the Lys residue by Arg in specific cleavage sequence (Asp)4-Lys. 3-6fold lower amounts of the catalytic subunit of enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)4-Arg cleavage sequence in comparison to native sequence (Asp)4-Lys. Reduced amount of non-specifically cleaved peptide fragments are observed during cleavage of (Asp)4-Lys/Arg mutated fusions |
718359 |
| 3.4.21.9 | more |
low enzyme concentrations protect hippocampal neurons against the death caused by 0.1 mM glutamate, via a proteinase activated receptor PAR1-dependent mechanism, while High concentrations of the enzyme causes the death of neurons mainly through necrosis |
717231 |
| 3.4.21.9 | more |
low enzyme light chain concentrations protect hippocampal neurons against the death caused by 0.1 mM glutamate, via a proteinase activated receptor PAR1-dependent mechanism, while high concentrations of enzyme light chain causes the death of neurons mainly through necrosis |
717231 |
| 3.4.21.9 | physiological function |
enteropeptidase is a serine protease secreted by the pancreas that converts inactive trypsinogen to active trypsin |
717431 |
| 3.4.21.9 | physiological function |
in duodenal fluid, the enzyme is responsible for causing pancreatitis in case of duodeno-pancreatic reflux |
732698 |
| 3.4.21.9 | physiological function |
the enzyme converts the inactive form of trypsinogen to active trypsin by endoproteolytic cleavage |
717891 |
| 3.4.21.9 | physiological function |
the enzyme enhances influenza A virus infection by activating trypsinogen in human cells. Exogenous enzyme expression is able to enhance the proliferation of influenza A virus in 293T human kidney cells |
753655 |
| 3.4.21.9 | physiological function |
the enzyme triggers the activation of the zymogens in pancreatic juice by converting trypsinogen into trypsin |
732803 |
