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EC Number
General Information
Commentary
Reference
malfunction
deficiency of factor D leads to exacerbated liver injury and inflammatory cells. The absence of Factor D and lack of C3b/iC3b/C3c deposition following CCl4-induced injury is associated with more severe and prolonged liver injury
metabolism
in humans neither MASP-1 nor MASP-3 are required for alternative pathway function. During MASP-1/-3 deficiency significant alternative pathway activity remains, indicating that mature factor D is present in the absence of MASP-1/-3
more
influence of buffer composition on the activity of the alternative pathway of complement activation in mice in the presence and the absence of the Masp1 gene products, overview
more
the substrate-binding, or exosite, region displays a well defined and rigid conformation. A salt bridge between Arg202 on the self-inhibitory loop and Asp177 locks the S1 pocket and rigidifies the exosite. Asp-His-Ser catalytic site. The enzyme exhibits conformational dynamics like thrombin, but unlike in thrombin a mechanism has evolved in factor D that locks the unbound native state into an ordered inactive conformation via the self-inhibitory loop. The Asp-His-Ser catalytic site of the enzyme is in an enzymatically active conformation induced by substrate binding at the exosite
physiological function
alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury in the liver. Acute toxic injury to the liver results in the death of hepatocytesby necrosis and apoptosis. If removal of damaged tissue is inadequate and injury persists, reorganization of the extracellular matrix is impaired
physiological function
human factor D is a self-inhibited thrombin-like serine proteinase that is critical for amplification of the complement immune response
physiological function
in total 150 gastric cancer patients who underwent radical gastrectomy are analyzed (75 cases presented with hepatic metastases and 75 cases presented without any recurrences). Significant association is shown between VEGF-D expression and hepatic metastasis from gastric cancer after radical gastrectomy
physiological function
interleukin-7/interleukin-7R induce VEGF-D up-regulation and promote lymphangiogenesis via c-Fos/c-Jun pathway in lung cancer
physiological function
mature factor D is required for the alternative complement pathway
physiological function
PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling
Results 1 - 10 of 12 > >>