EC Number   |
General Information |
Reference  |
|---|
   3.4.17.23 | malfunction |
inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats |
707036 |
| 3.4.17.23 | physiological function |
ACE2 is a regulator of the renin-angiotensin system |
707055 |
| 3.4.17.23 | malfunction |
loss of ACE2 function is implicated in severe acute respiratory syndrome, SARS, pathogenesis |
707074 |
| 3.4.17.23 | physiological function |
soluble sACE2 may play a role in modifying peptides in airway surface liquid involved in processes such as inflammation. The membrane-associated form of ACE2 serves as a SARS-CoV receptor in vitro, and shedding is not required for infection to occur |
707074 |
| 3.4.17.23 | malfunction |
loss of ACE2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction, MI, overview. ACE2 deficiency leads to increased matrix metalloproteinases 2 and 9 levels with MMP2 activation in the infarct and peri-infarct regions, as well as increased gelatinase activity leading to a disrupted extracellular matrix structure after MI. Loss of ACE2 also leads to increased neutrophilic infiltration in the infarct and peri-infarct regions, resulting in upregulation of inflammatory cytokines, interferon-gamma, interleukin-6, and the chemokine, monocyte chemoattractant protein-1, as well as increased phosphorylation of ERK1/2 and JNK1/2 signaling pathways |
708141 |
| 3.4.17.23 | physiological function |
ACE2 is a monocarboxypeptidase that metabolizes Ang II into Ang 1-7, thereby functioning as a negative regulator of the renin-angiotensin system |
708141 |
| 3.4.17.23 | physiological function |
ACE 2 balances the status of the renin-angiotensin system by degrading angiotensin II and generating angiotensin-(1-7). ACE2 induces overexpression of connective tissue growth factor, which is inhibited by blockade of theMas receptor with A779, overview |
708195 |
| 3.4.17.23 | physiological function |
angiotensin II is a critical factor for stimulating cardiocyte hypertrophy, fibroblast proliferation and extracellular matrix production in left ventricular remodeling. ACE2 overexpression attenuates left ventricular myocardial fibrosis and improves left ventricular remodeling and systolic function, overview |
708649 |
| 3.4.17.23 | malfunction |
angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice |
708683 |
| 3.4.17.23 | physiological function |
ACE2 is a component of the brain renin-angiotensin system participating in the central regulation of blood pressure |
708683 |
