EC Number   |
General Information |
Reference |
|---|
   3.4.17.23 | physiological function |
ACE 2 balances the status of the renin-angiotensin system by degrading angiotensin II and generating angiotensin-(1-7). ACE2 induces overexpression of connective tissue growth factor, which is inhibited by blockade of theMas receptor with A779, overview |
708195 |
| 3.4.17.23 | malfunction |
ACE2 activity shows a tendency to decrease in the serum of Alzheimer disease patients compared with normal controls |
732366 |
| 3.4.17.23 | physiological function |
ACE2 binds the prototype SARS-CoV-2 receptor-binding domain with a dissociation constant (KD) of 24.63 nM. Receptor-binding domains from SARS-CoV-2 variants alpha, beta, and gamma demonstrate enhanced affinities, ranging from 1.78- to 4.56fold increase. Variant omicron, along with delta receptor-binding domain, shows no significant change in binding affinities when compared with those of the prototype domain |
764429 |
| 3.4.17.23 | malfunction |
ACE2 deficiency increases the severity of H7N9-induced lung injury in a mouse model |
732911 |
| 3.4.17.23 | physiological function |
ACE2 functions as a carboxypeptidase that can cleave several endogenous substrates, including angiotensin II, thus regulating blood pressure and vascular tone |
763217 |
| 3.4.17.23 | metabolism |
ACE2 ia a component of the renin-angiotensin system, RAS |
710171 |
| 3.4.17.23 | physiological function |
ACE2 is a component of the brain renin-angiotensin system participating in the central regulation of blood pressure |
708683 |
| 3.4.17.23 | physiological function |
ACE2 is a monocarboxypeptidase that metabolizes Ang II into Ang 1-7, thereby functioning as a negative regulator of the renin-angiotensin system |
708141 |
| 3.4.17.23 | physiological function |
ACE2 is a regulator of the renin-angiotensin system |
707055 |
| 3.4.17.23 | physiological function |
ACE2 is a regulator of the renin-angiotensin system,. Losartan, a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in regulating ACE2 |
710616 |
