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Results 1 - 10 of 26 > >>
EC Number
General Information
Commentary
Reference
malfunction
ACE2 activity shows a tendency to decrease in the serum of Alzheimer disease patients compared with normal controls
malfunction
ACE2 deficiency increases the severity of H7N9-induced lung injury in a mouse model; mice infected with influenza H7N9 virus downregulate ACE2 protein markedly on day 3 after infection
malfunction
ACE2 knockout mice are more susceptible than the wild-type mice to high-fat diet-induced beta cell dysfunction. The TUNEL-positive area of the pancreatic islets and the expression levels of IL-1beta and iNOS are markedly increased in the ACE2 knockout mice compared with their wild-type littermates. The Mas-silenced MS-1 cells are more sensitive to palmitate-induced dysfunction and apoptosis in vitro
malfunction
ACE2 over-expression in the brain decreases Ang-II mediated cardiac hypertrophy and collagen deposition, reduces urinary norepinephrine levels and partially protectes syn-hACE2 transgenic (SA) mice, in which the human ACE2 transgene is selectively targeted to neurons, from sympathetic-mediated cardiac hypertrophy and fibrosis
malfunction
angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
malfunction
genetic inactivation of ACE2 causes severe lung injury in H5N1-challenged mice. Administration of recombinant ACE2 ameliorates avian influenza H5N1 virus-induced lung injury in mice
malfunction
inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
malfunction
loss of ACE2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction, MI, overview. ACE2 deficiency leads to increased matrix metalloproteinases 2 and 9 levels with MMP2 activation in the infarct and peri-infarct regions, as well as increased gelatinase activity leading to a disrupted extracellular matrix structure after MI. Loss of ACE2 also leads to increased neutrophilic infiltration in the infarct and peri-infarct regions, resulting in upregulation of inflammatory cytokines, interferon-gamma, interleukin-6, and the chemokine, monocyte chemoattractant protein-1, as well as increased phosphorylation of ERK1/2 and JNK1/2 signaling pathways
malfunction
loss of ACE2 function is implicated in severe acute respiratory syndrome, SARS, pathogenesis
malfunction
postural tachycardia syndrome is associated with increased plasma angiotensin-II. ACE2 effects are blunted in low flow postural tachycardia syndrome, POTS, and restored by the ACE2 product angiotensin-(1-7)
Results 1 - 10 of 26 > >>