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3.1.2.12
metabolism
FrmB activates the prodrug bis(pivaloyloxymethyl) (1-hydroxy-2-oxopiperidin-3-yl)phosphonate. Mutation of FrmB renders Staphylococcus aureus sensitive to bis(pivaloyloxymethyl) (1-hydroxy-2-oxopiperidin-3-yl)phosphonate
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760979
3.1.2.12
physiological function
FrmB has the highest activity toward oxygen ethers. FrmB hydrolyzes unbranched substrates with little regard for chain length or the end-of-chain bulk within the tested substrates. Branching at the position following the ester carbonyl is deleterious to FrmB activity. When oxygen is included in the chain, positioning at the beta-position to the carbonyl is strongly preferred over the gamma-position
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760979
3.1.2.12
physiological function
overexpression of ESD significantly suppresses foot-and-mouth disease virus FMDV replication. Knockdown of ESD expression enhances virus replication. Sendai-virus-induced interferon signaling is enhanced by upregulation of ESD. ESD protein enhances IRF3 phosphorylation during FMDV infection. Overexpression of ESD also promotes the expression of various antiviral interferon-stimulated genes, and knockdown of ESD impairs the expression of these antiviral genes during FMDV infection
751579
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