EC Number   |
General Information  |
Reference |
|---|
   2.7.8.43 | evolution |
ethanolamine transferases are members of the YhjW/YjdB/YijP superfamily |
734476 |
| 2.7.8.43 | evolution |
LptA is a member of the lipopolysaccharide transport protein (Lpt) family |
752134 |
| 2.7.8.43 | evolution |
the eptC gene (locus tag Cj0256) is clustered in a family of inner-membrane metalloenzymes (COG2194) containing a fivehelix transmembrane domain and a periplasmic catalytic domain that is currently grouped in the sulfatase family |
-, 739786 |
| 2.7.8.43 | malfunction |
a mutant LptA protein unable to form oligomers has an altered affinity for LPS |
752134 |
| 2.7.8.43 | malfunction |
a pbgP/pmrC double mutant resembled a pmrA mutant both in its lipid A profile and in its susceptibility to polymyxin B, mutation of the pmrC gene results in lipid A that lacks phosphoethanolamine. The inactivation of both the pmrC and pbgP genes in the polymyxin B-resistant pmrA505 genetic background reduces polymyxin B resistance to the levels of the pmrA null mutant |
734064 |
| 2.7.8.43 | malfunction |
although Salmonella lipid A is more prevalently modified with L-4-aminoarabinose, loss of Salmonella lpxT greatly increases modification of lipid A through enzyme EptA, and LpxT-dependent lipid A modification is not restored in the DELTAeptA mutant. LpxT catalyses the phosphorylation of lipid A at the 1-position forming 1-diphosphate lipid A increasing the negative charge of the bacterial surface |
-, 723212 |
| 2.7.8.43 | malfunction |
deletion of colR and of eptA results in loss of Zn2+-induced phosphatidylethanolamine modification of Pseudomonas aeruginosa lipid A. colR deletion mutant complementation restores Zn2+-dependent eptAPa transcription by more than fourfold |
739106 |
| 2.7.8.43 | malfunction |
deletion of gene cj0256 results in the loss of phosphoethanolamine modification of lipid A and sensitivity to CAMPs, polymyxin B. Cj0256 mutants show decreased motility and greatly reduced flagella production. Interruption of cj0256 results in the absence of pEtN modifications on lipid A as well as FlgG. The cj0256 mutant showed a 20fold increase in sensitivity to the cationic antimicrobial peptide, polymyxin B, as well as a decrease in motility |
735157 |
| 2.7.8.43 | malfunction |
deletion of two putative PEA transferase genes in Haemophilus ducreyi increases susceptibility to HBD-3 |
-, 735018 |
| 2.7.8.43 | malfunction |
disruption of gene lptA leads to a approximately 10fold decrease in Neisseria meningitidis adhesion to four kinds of human endothelial and epithelial cell lines. Complementation with the lptA gene in the DELTAlptA mutant restores wild-type adherence |
733962 |
