EC Number   |
General Information |
Reference  |
|---|
    2.7.7.23 | more |
GlmU from Mycobacterium tuberculosis possesses a unique 30-residue extension at the C-terminus |
720042 |
| 2.7.7.23 | physiological function |
N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU) is a bifunctional enzyme involved in bacterial cell wall synthesis and is exclusive to prokaryotes |
720042 |
| 2.7.7.23 | malfunction |
the inhibition of this enzyme results in the fungal cell death |
722022 |
| 2.7.7.23 | physiological function |
UDP-N-acetylglucosamine pyrophosphorylase (UNAcP) is a key enzyme to construct the fungal cell wall |
722022 |
| 2.7.7.23 | physiological function |
down-regulation of transcripts by RNA interference prevents larval growth or results in pupal paralysis, depending on time of injection of double-stranded RNAs. Down-regulation of transcripts at the mature adult stage results in cessation of oviposition in females, as well as fat body depletion and eventual death in both sexes |
722387 |
| 2.7.7.23 | physiological function |
down-regulation of transcripts by RNA interference results for isoform UAP1 in specific arrest at the larval-larval, larval-pupal or pupal-adult molts, depending on time of injection of double-stranded RNAs, loss of structural integrity and chitin staining and loss of peritrophic matrix-associated chitin. Down-regulation of transcripts at the mature adult stage results in cessation of oviposition in females, as well as fat body depletion and eventual death in both sexes |
722387 |
| 2.7.7.23 | physiological function |
because the multifunctional ST0452 protein is capable of catalyzing the last two reactions (Ec 2.3.1.157 and EC 2.7.7.23 (UDP-N-acetylglucosamine diphosphorylase)) of the bacteria-type four-step biosynthesis pathway of UDP-GlcNAc from fructose 6-phosphate, the ST0452 protein plays an important role for the bacteria-type UDP-GlcNAc biosynthesis pathway in this archaeon |
-, 725249 |
| 2.7.7.23 | physiological function |
the enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms |
-, 725308 |
| 2.7.7.23 | more |
the ST0452 protein contains only two Cys residues, it is unlikely that CysCys bonds contribute to its thermostability |
-, 729696 |
| 2.7.7.23 | evolution |
the N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is a bifunctional enzyme exclusive to prokaryotes, that belongs to the family of sugar nucleotidyltransferases (SNTs) |
735396 |
