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General Information
Commentary
Reference
evolution
although Entamoeba histolytica UAP exhibits the same three-domain global architecture as other UAPs, it appears to lack three alpha-helices at the N-terminus and contains two amino acids in the allosteric pocket that make it appear more like the enzyme from the human host than that from the other parasite Trypanosoma brucei; although Entamoeba histolytica UAP exhibits the same three-domain global architecture as other UAPs, it appears to lack three alpha-helices at the N-terminus and contains two amino acids in the allosteric pocket that make it appear more like the enzyme from the human host than that from the other parasite Trypanosoma brucei
evolution
GlmU belongs to the large family of sugar nucleotidyl transferases, which can be classified into group-I, which employs the two-metal mechanism-B as in GlmU, and group-II that employs a variant one metal mechanism-B, wherein the role of Mg2+ A is substituted by a conserved lysine. Eukaryotic sugar nucleotidyl transferases appear confined to group-II, structure-based sequence comparisons of sugar nucleotidyl transferases
evolution
organization andexpression of the mmy gene in Drosophila species, overview
evolution
the GlmU proteins encoded by Yersinia pestis and Yersinia pseudotuberculosis are identical in amino acid sequence
evolution
the N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is a bifunctional enzyme exclusive to prokaryotes, that belongs to the family of sugar nucleotidyltransferases (SNTs)
evolution
UAP isozymes are encoded by two different genes, LmUAP1 and LmUAP2; UAP isozymes are encoded by two different genes, LmUAP1 and LmUAP2
malfunction
GlmUMtb depletion perturbs cell wall structure and affects the bacterial survival in normoxia, overview
malfunction
independently-derived mmy mutants exhibit a variety of highly penetrant phenotypes, ranging from cuticle defects associated with a failure to synthesize chitin to cuticle defects associated with well-characterized Dpp-dependent closure abnormalities (dorsal closure and head involution). In particular, the mmy-associated cuticle defects are identical to those resulting from loss-of-function mutations in raw and anterior-open
malfunction
knockdown of LdUAP1 reduces chitin contents in whole larvae and integument samples, thins tracheal taenidia, impairs larval-larval molt, larval-pupal ecdysis and adult emergence. Combined knockdown of LdUAP1 and LdUAP2 causes an additive negative effect. Phenotypes, overview; silencing of LdUAP2 significantly reduces foliage consumption, decreases chitin content in midgut samples, damages PM, and retards larval growth. The resulting larvae have lighter fresh weights, smaller body sizes and depleted fat body. As a result, the development is arrested. Combined knockdown of LdUAP1 and LdUAP2 causes an additive negative effect. Phenotypes, overview
malfunction
the inhibition of this enzyme results in the fungal cell death
Results 1 - 10 of 44 > >>