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Results 1 - 3 of 3
EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.7.1.228physiological function Ipt1 (inositolphosphotransferase 1) is required for synthesis of mannose-(inositol-P)2-ceramide. An Ipt1-deletion strain fails to accumulate mannose-(inositol-P)2-ceramide and instead accumulates increased amounts of the precursor mannose-inositol-P-ceramide. The mutant also fails to incorporate radioactive precursors into mannose-(inositol-P)2-ceramide, and membranes prepared from it do not incorporate [3H-inositol]phosphatidylinositol into mannose-(inositol-P)2-ceramide. An Ipt1-deletion mutant has no severe phenotypic effects but is slightly more resistant to growth inhibition by calcium ions 754049
Display the reaction diagram Show all sequences 2.7.1.228physiological function loss of IPT1 has complex effects on drug resistance of the resulting strain. Transcription of the IPT1 gene is responsive to changes in activity of transcription factors Pdr1p and Pdr3p. Pdr1p and Pdr3p may act to modulate the lipid composition of membranes 754060
Display the reaction diagram Show all sequences 2.7.1.228physiological function when grown in half-strength potato dextrose medium, an Ipt1 deletion mutant is sensitive to bacterial cyclic lipodepsipeptide syringomycin E and plant defensin AMP1 and produces small amounts of mannosyldiinositolphosphoceramide. Susceptibility of Saccharomyces cerevisiae for the antifungal peptides syringomycin E and AMP1 depends on the presence of mannosyldiinositolphosphoceramide and not necessarily on a functional IPT1 gene -, 753586
Results 1 - 3 of 3