EC Number   |
General Information  |
Reference |
|---|
    2.6.1.19 | evolution |
EctB-type proteins are highly conserved |
-, 759234 |
| 2.6.1.19 | evolution |
enzyme Atu3300 is predicted by Pfam to include an Aminotrans_3 (aminotransferase class-III) domain, which is characteristic of aminotransferases |
-, 760153 |
| 2.6.1.19 | evolution |
transaminases structure comparisons, overview |
-, 758736 |
| 2.6.1.19 | malfunction |
constitutive overexpression lines of GABA-T are generated in Arabidopsis. Brief cold treatments increases leaf GABA concentrations in both the WT and transgenic line OX1, but the concentrations in OX1 is consistently lower. These findings confirm that GABA-T limits the catabolism of GABA when its production is stimulated by stress, and suggest a bioengineering strategy for improving the availability of succinate semialdehyde for the Krebs cycle or GLYR1, a potential redox-modulating reaction during stress |
721953 |
| 2.6.1.19 | malfunction |
deletion of the gabT gene encoding GABA-T cannot prevent GABA from decomposing at neutral pH. An additional transaminase gene, NCgl2515, is deleted in a gabT-deleted GAD strain, but the GABA concentration in this gabT NCgl2515-deleted GAD strain remains unaltered when pH is maintained at pH 7.5-7.8, demonstrating that GABA decomposition is reduced |
-, 760076 |
| 2.6.1.19 | malfunction |
deletion of the gabT gene encoding GABA-T cannot prevent GABA from decomposing at neutral pH. An additional transaminase gene, NCgl2515, is deleted in a gabT-deleted GAD strain, but the GABA concentration in this gabT-deleted GAD strain NCgl2515 remains unaltered when pH is maintained at pH 7.5-8.0, demonstrating that GABA decomposition is reduced |
-, 760076 |
| 2.6.1.19 | malfunction |
IncRNAs play an important role in the regulation of gene expression. Differential expression of lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS), profiling to construct a 4-aminobutyrate aminotransferase (ABAT)-DEL-DEM coexpression network in MDS development using the GO and KEGG pathway and network analyses. Compared with controls, there are 543 DELs and 2705 DEMs in MDS patients, among which 285 (52.5%) DELs are downregulated and 258 (47.5%) DELs are upregulated, whereas 1521 (56.2%) DEMs are downregulated and 1184 (43.70%) DEMs are upregulated in MDS patients. The ABAT-DEL-DEM coexpression network contains six DELs that are coexpressed with ABAT in MDS |
759881 |
| 2.6.1.19 | malfunction |
inhibition of GABA aminotransferase (GABA-AT), the enzyme that degrades GABA, is a possible strategy for the treatment of substance abuse. The raised GABA levels that occur as a consequence of the inhibition antagonize the rapid release of dopamine in the ventral striatum (nucleus accumbens) that follows an acute challenge by an addictive substance. In addition, increased GABA levels are also known to elicit an anticonvulsant effect in patients with epilepsy |
759407 |
| 2.6.1.19 | malfunction |
inhibition of GABAT is known to boost GABA concentration in the brain and thereby alleviates spasticity. Therefore, attenuating GABAT activity and enhancing GABA expression are a promising way to relieve spasticity following stroke. Waggle needling attenuates gamma-aminobutyric acid transaminase expression in the injured brain of rats with post-stroke spasticity comparable to the effect of baclofen |
-, 759852 |
| 2.6.1.19 | malfunction |
patients with GABA-T deficiency show severe, nonspecific neurological manifestations, including psychomotor retardation, epilepsy, hypotonia, and hyperreflexia |
704969 |
