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Results 1 - 10 of 13 > >>
EC Number
General Information
Commentary
Reference
malfunction
mice lacking both isoforms FUT4 and FUT7 have a shorter time to occlusive thrombus formation in the injured carotid artery and a higher mortality due to collagen/epinephrine-induced pulmonary thromboemboli. FUT4-, but not FUT7, -deficient mice have increased pulmonary thromboembolism-induced mortality and decreased thromboemboli dissolution in vivo
malfunction
sperm isoform FUT5 pretreatment or blocking suppresses the protective effect of OE-E6/E7 membrane proteins on sperm motility
metabolism
isoform Fut3 expression drives sialyl Lewis A synthesis in V6 variant of CD44-expressing cells
metabolism
isoforms FUT4 and FUT7 are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands
physiological function
alpha(1,3) fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation
physiological function
alpha-1,3 fucosyltransferases can enhance metastatic efficiency of prostate cancer by triggering an endothelial selectin-dependent trafficking mechanism. Upregulated FT3, FT6, or FT7 expression induces robust prostate cancer PC-3 cell adhesion to bone marrow endothelium and to inflamed postcapillary venules in an endothelial selectin-dependent manner. FT3, FT6, and FT7 induce sialyl Lewis X expression on metastatic prostate cancer PC-3 cells. Elevated FT7 expression promotes PC-3 cell trafficking to and retention in bone marrow through an endothelial selectin dependent event
physiological function
final glycosylation step in sialyl Lewis x and sialyl Lewis a biosynthesis in MKN45 cell line is associated to FUT5, which efficiently fucosylates sialyl Lewis precursors on glycoproteins; fucosyltransferases are responsible for the synthesis of sialyl Lewis a and sialyl Lewis x in gastrointestinal cell lines
physiological function
Helicobacter pylori-binding glycosphingolipid isolated from stomach of transgenic alpha-1,3/4-fucosyltransferase-expressing mice as a Fucalpha2Galbeta3 (Fucalpha4)GalNAcbeta4Galbeta4Glcbeta1Cer, i.e. a Leb-like glycosphingolipid on a ganglio core structure. Two other glycosphingolipids are isolated from the mouse stomach epithelium that are found to be nonbinding with regard to Helicobacter pylori, which is a pentaglycosylceramide, GalNAcbeta3Galalpha3(Fucalpha2)Galbeta4Glcbeta1Cer, in which the isoglobo tetrasaccharide is combined with Fucalpha2 to yield an isoglobotetraosylceramide with an internal blood group B determinant. The second one is an elongated fucosyl-gangliotetraosylceramide, GalNAcbeta3(Fucalpha2)Galbeta3GalNAcbeta4Galbeta4Glcbeta1Cer
physiological function
isoform FUT4 and FUT7 activity regulates thrombosis in a P-selectine and P-selectin glycoprotein ligand-1-independent manner. Isoform FUT4 activity is important for thrombolysis
physiological function
role in synthesis of parasitic GalNAc beta1-4(Fuc alpha1-3)GlcNAc beta-R antigen
Results 1 - 10 of 13 > >>