EC Number   |
General Information  |
Reference |
|---|
   2.4.1.288 | metabolism |
GlfT2 catalyzes the formation of mycobacterial galactan, mediating galactan polymerization using only one active site that manifests dual regioselectivity |
-, 718920 |
| 2.4.1.288 | metabolism |
the enzyme catalyzes the addition of the third and subsequent Galf residues, but not the first two, to the lipid template in galactan synthesis |
719712 |
| 2.4.1.288 | metabolism |
the enzyme catalyzes the formation of both beta-5-linked and beta-6-linked galactofuranoses and is responsible for the synthesis of the bulk galactan portion of AG |
-, 719707 |
| 2.4.1.288 | physiological function |
GlfT2 is essential for mycobacterial cell wall biosynthesis |
720037 |
| 2.4.1.288 | physiological function |
the enzyme mediates the cell wall galactan production through a sequence-specific polymerization |
719665 |
| 2.4.1.288 | physiological function |
the free-energy barriers for beta-(1-6) and beta-(1-5) linkages are mainly the same, 29.6 kcal/mol for the beta-(1-6) reaction and 28.2 kcal/mol for the beta-(1-5) reaction. Both reactions occur at a single catalytic site with a SN2-type reaction mechanism with a dissociative oxocarbenium ion-like transition state for both the beta-(1-6) and beta-(1-5) reactions. In both reactions the furanose ring adopts an utterly flat ring in the transition state |
-, 759070 |
