EC Number   |
General Information |
Reference  |
|---|
    2.3.3.8 | metabolism |
involved in lung cancer pathogenesis |
703014 |
| 2.3.3.8 | malfunction |
inhibition of the enzyme suppresses in vitro glioblastoma cell migration, clonogenicity and brain invasion under glycolytic conditions and enhances the suppressive effects of a Met inhibitor on cell migration |
704077 |
| 2.3.3.8 | physiological function |
ATP citrate lyase is a positive regulator of glycolytic function in glioblastomas |
704077 |
| 2.3.3.8 | malfunction |
overexpression of the enzyme is observed in nonalcoholic fatty liver disease. Increased enzyme activity is associated with hypocituria, nonalcoholic fatty liver disease, and tumor cell growth. Decreased enzyme activity is associated with type 2 diabetes. ACLY knockdown or inhibition leads to a decrease in glucose-induced insulin secretion |
718760 |
| 2.3.3.8 | metabolism |
the enzyme is involved in citrate metabolism |
718760 |
| 2.3.3.8 | physiological function |
the enzyme is essentially required for embryonic development. Increased enzyme activity is found in the fetal development of the brain |
718760 |
| 2.3.3.8 | malfunction |
loss of ATP-citrate lyase results in severe developmental effects, with the production of asexual spores (conidia) being greatly reduced and a complete absence of sexual development |
-, 719383 |
| 2.3.3.8 | physiological function |
ATP-citrate lyase is required for development in Aspergillus nidulans |
-, 719383 |
| 2.3.3.8 | malfunction |
deletion of the enzyme results in a complete loss of self and female fertility as well as a reduction in asexual reproduction, virulence, and trichothecene production. Although lipid synthesis is not affected by enzyme deletion, histone acetylation is dramatically reduced in the enzyme deletion mutants during sexual development |
-, 719545 |
| 2.3.3.8 | physiological function |
ATP citrate lyase is required for normal sexual and asexual development in Gibberella zeae |
-, 719545 |
