EC Number   |
General Information |
Reference |
|---|
    2.3.3.8 | metabolism |
acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury |
758518 |
| 2.3.3.8 | physiological function |
ATP citrate lyase is a positive regulator of glycolytic function in glioblastomas |
704077 |
| 2.3.3.8 | metabolism |
ATP citrate lyase is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis |
758267 |
| 2.3.3.8 | physiological function |
ATP citrate lyase is required for normal sexual and asexual development in Gibberella zeae |
-, 719545 |
| 2.3.3.8 | malfunction |
ATP citrate lyase knockdown induces proliferation arrest, cell-cycle arrest, and apoptosis in cancer cells and results in elevated expression of acyl-CoA synthetase short-chain family member 2 |
720439 |
| 2.3.3.8 | physiological function |
ATP citrate lyase plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. The enzyme increases myoblast and satellite cell differentiation in vitro. It increases MYOD expression by acetyl-H3(K9/14/27) enrichment at the MYOD promoter. It acts downstream of IGF-1 to stimulate myogenesis. IT improves muscle regeneration following cardiotoxin-induced injury |
756395 |
| 2.3.3.8 | malfunction |
ATP citrate lyase silencing impairs myoblast and satellite cell differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD |
756395 |
| 2.3.3.8 | metabolism |
ATP-citrate lyase is a central metabolic enzyme. The acetyl-CoA product is crucial for the metabolism of fatty acids, the biosynthesis of cholesterol, and the acetylation and prenylation of proteins |
757803 |
| 2.3.3.8 | physiological function |
ATP-citrate lyase is required for development in Aspergillus nidulans |
-, 719383 |
| 2.3.3.8 | malfunction |
decrease in ATP level, energy charge, and fatty acid content in mutant edt1 anthers |
758054 |
