EC Number   |
General Information |
Reference  |
|---|
   2.3.1.B41 | physiological function |
the enzyme regulates the expression of surface antigens to evade the detection by host immune surveillance. The physiological function of PfSir2A in antigen variation may be achieved by removing medium and long chain fatty acyl groups from protein lysine residues |
-, 728852 |
| 2.3.1.B41 | metabolism |
SIRT6 acts as a tumor suppressor in human glioma. SIRT6 binds to poly(C)-binding protein 2 (PCBP2) promoter region and deacetylates H3K9ac, resulting in transcription regression |
729145 |
| 2.3.1.B41 | physiological function |
Sirt6 is a critical regulator of endothelial senescence |
729362 |
| 2.3.1.B41 | malfunction |
SIRT6 loss suppresses proliferation and epidermal hyperplasia in mouse skin. Skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis |
729520 |
| 2.3.1.B41 | metabolism |
SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis |
729520 |
| 2.3.1.B41 | malfunction |
knock-down of SIRT6 does not sensitize bladder cancer cell lines to DNA damaging drugs |
729849 |
| 2.3.1.B41 | metabolism |
SIRT6 suppresses glycolysis in bladder cancer cells |
729849 |
| 2.3.1.B41 | physiological function |
SIRT6 is involved in mechanisms of stress protection. Function of SIRT6 in the maintenance of stress granules in response to stress |
730101 |
| 2.3.1.B41 | metabolism |
SIRT6 promotes the secretion of tumor necrosis factor alpha by removing the fatty acyl modification on K19 and K20 of TNFalpha |
730464 |
| 2.3.1.B41 | metabolism |
SIRT6 may play a role in synaptic function and neuronal maturation and it may be implicated in the regulation of neuronal survival |
730473 |
