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Results 1 - 10 of 10
EC Number General Information Commentary Reference
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221metabolism PksA is involved in the synthesis of norsolorinic acid, an intermediate in the biosynthesis of the environmental carcinogen aflatoxin B1 721052
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221physiological function PksA, which initiates biosynthesis of the environmental carcinogen aflatoxin B1, is one of the multidomain iterative polyketide synthases, IPKSs 721052
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221metabolism the the norsolorinic acid anthrone-producing polyketide synthase, PksA, is involved in the aflatoxin biosynthetic pathway in Aspergillus parasiticus 722459
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221more the enzyme also has an editing function for the C-terminal thioesterase domain beyond its synthetic role in Claisen/Dieckmann cyclization and product release. Domain architecture and expected enzyme-bound intermediates of PksA, overview 722459
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221evolution the pksA gene is located in the aflatoxin pathway gene cluster and is linked to the nor-1 gene, an aflatoxin pathway gene required for converting norsolorinic acid to averantin -, 723194
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221malfunction strain SRRC 2043 is a disruption mutant defective in the pksA locus. Disruption of pksA results in an inability to produce aflatoxin intermediates -, 723194
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221metabolism pksA is a polyketide synthase gene required for the early steps of aflatoxin biosynthesis -, 723194
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221metabolism biosynthesis of norsolorinic acid anthrone by PksA, detailed overview 723262
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221metabolism polyketide synthase A is a multidomain PKS central to the biosynthesis of aflatoxin B1, a potent environmental carcinogen 723638
Show all pathways known for 2.3.1.221Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.221more the synthetic versatility of thioesterase domains in fungal nonreducing, iterative PKSs extends to Claisen cyclase chemistry by catalyzing C-C ring closure reactions as opposed to thioester hydrolysis or O-C/N-C macrocyclization observed in other thioesterase structures. Catalysis of C-C bond formation as a product release mechanism dramatically expands the synthetic potential of PKSs, structural analyses of the thioesterase/CLC domain in polyketide synthase A 723638
Results 1 - 10 of 10