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EC Number
General Information
Commentary
Reference
malfunction
a tmcA deletion strain does not show a growth defect. Thus, this modification does not appear to be required for faithful translation in an otherwise wild-type strain. A tmcA/dusC double deletion strain has a severe cold-sensitive growth defect
physiological function
posttranscriptional RNA modifications in the anticodon of transfer RNAs contributes to the high fidelity of protein synthesis. In eubacteria, two genome-encoded tRNA species bear the same CAU sequence as the anticodons, which are differentiated by modified cytidines at the wobble positions. The elongator tRNAMet accepts an acetyl moiety at the wobble base to form N4-acetylcytidine (ac4C): an inherent modification ensures precise decoding of the AUG codon by strengthening C-G base-pair interaction and concurrently preventing misreading of the near cognate AUA codon
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