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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56physiological function mRNA guanosine cap by RNA guanine-7-methyltransferase is rate-limiting for cellular cap-methyltransferase activity, and enhancing this activity promotes cyclin D1 expression and cell formation 706020
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56malfunction mutation defective in N-7 methylation but not 2-O'-methylation is lethal for DNV replication 721100
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56physiological function N7 cap methylation is essential for viral replication 705423
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56malfunction significant loss of RNA polymerase II gene occupancy is observed on enzyme suppression. Enzyme suppression inhibits transcriptional markers including histone H2BK120 ubiquitination, H3K4 and H3K36 methylation, RNA polymerase II C-terminal domain S5 and S2 phosphorylation, and PAFc recruitment 756401
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56metabolism the enzyme in complex with RNMT-activating miniprotein catalyzes the formation of a N7-methylated guanosine cap structure on the 5' end of nascent RNA polymerase II transcripts. The mRNA cap protects the primary transcript from exonucleases and recruits cap binding complexes that mediate RNA processing, export and translation 757862
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56physiological function the enzyme promotes RNA polymerase II-dependent transcription independent of mRNA capping and translation 756401
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.56malfunction when cellular enzyme activity is experimentally reduced by 50%, the proliferation rate of nontransformed mammary epithelial cells is unchanged, whereas a subset of breast cancer cell lines exhibit reduced proliferation and increased apoptosis 757896
Results 1 - 7 of 7