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General Information
homozygous disruption of Hypb impairs histone H3(K36) trimethylation but not mono- or dimethylation, and resulted in embryonic lethality at E10.5-E11.5. Severe vascular defects are observed in the Hypb-deficient embryo, yolk sac, and placenta
human endothelial cells with siRNA-mediated suppression of HYPB, show defects in cell migration, tubule formation, and invasion during vessel formation
physiological function
histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
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