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EC Number
General Information
Commentary
Reference
evolution
the KsgA family belongs tothe group of S-adenosyl-L-methionine-dependent methyltransferases, known as class I MTases, KsgA is related to DNA adenosine methyltransferases, which transfer only a single methyl group to their target adenosine residue. Part of the discrimination between mono- and dimethyltransferase activity lies in a single residue in the active site, L114; this residue is part of a conserved motif, known as motif IV, which is common to a large group of S-adenosyl-L-methionine-dependent methyltransferases
malfunction
acquisition of high-level resistance to kasugamycin at an extraordinarily high frequency, ksgA mutants display a disadvantage in overall fitness compared to the parent strain
malfunction
cold sensitivity and altered ribosomal profiles are associated with a DELTAksgA genotype in Escherichia coli
malfunction
loss of this dimethylation confers resistance to the antibiotic kasugamycin
malfunction
mutants which contain a frameshift mutation in ksgA are severely impaired for growth
malfunction
spontaneous KSGR mutants in Neisseria gonorrhoeae arise through mutations in ksgA, which are likely to reduce KsgA activity and lead to undermethylated rRNA and thus resistance to kasugamycin
malfunction
strains lacking the methylase are resistant to kasugamycin
malfunction
the enzyme knockout strain is sensitive to oxidative stress and has a lower survival rate in murine macrophage RAW264.7 cells than the parent strain
malfunction
the inability to form dimethyladenine in the 16S rRNA-derived oligonucleotide is accompanied by muatation from kasugamycin sensitivity to resistance
malfunction
yeast enzyme Dim1 complements heterologously for ksgA- mutation in Escherichia coli, demonstrating functional equivalence of the two proteins
Results 1 - 10 of 17 > >>