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General Information
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Reference
physiological function
deletion of MetE gene results in a rapid growth and glucose utilisation rate and almost loss of spinosad production. A total of 1440 genes are differentially expressed in wild-type and MetE mutant strains. The differentially expressed enzymes are mainly involved in primary metabolism and genetic information processing
physiological function
on minimum medium, MET6 null mutants are auxotrophic for methionine. Even when grown in presence of excess methionine, mutants display developmental defects, such as reduced mycelium pigmentation, aerial hypha formation and sporulation, and metabolic signatures such as increased levels of cysteine, cystathionine, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine while methionine and glutathione levels remain unchanged. the null mutant shows over-expression of CBS1 involved in the reversed transsulfuration pathway that metabolizes homocysteine into cysteine and SAM1 and SAHH1 involved in the methyl cycle. MET6 null mutants are non-pathogenic on both barley and rice leaves, and are defective in appressorium-mediated penetration and invasive infectious growth
Results 1 - 2 of 2