EC Number   |
General Information |
Reference  |
|---|
   1.8.3.5 | metabolism |
liquid-phase IEF is used to resolve LDL proteins into well-defined fractions on the basis of pI. Besides known LDL-associated proteins, the presence of proteins not previously described to reside in LDL, including prenylcysteine lyase (PCL1) is shown. The finding that an enzyme associated with atherogenic lipoproteins can itself generate an oxidant suggests that PCL1 may play a significant role in atherogenesis |
706670 |
| 1.8.3.5 | malfunction |
farnesyl-L-cysteine accumulates in fcly mutants, leading to competitive inhibition of isoprenylcysteine methyltransferase activity, which show enhanced response to abscisic acid reversable by isoprenylcysteine methyltransferase overexpression. The abscisic acid hypersensitive phenotype of fcly plants is the result of farnesyl-L-cysteine accumulation and inhibition of isoprenylcysteine methyltransferase |
710018 |
| 1.8.3.5 | physiological function |
the specific farnesylcysteine lyase is responsible for the oxidative metabolism of FC to farnesal and cysteine |
710018 |
| 1.8.3.5 | malfunction |
T-DNA insertions into the FCLY gene cause significant decreases in FC lyase activity and an enhanced response to abscisic acid in seed germination assays. The effects of FCLY mutations on abscisic acidsensitivity are even greater in the presence of exogenous S-(2E,6E)-farnesyl-L-cysteine |
-, 710279 |
| 1.8.3.5 | metabolism |
the enzyme is involved in the salvage cycle for S-(2E,6E)-farnesyl diphosphate in plants, overview |
-, 710279 |
| 1.8.3.5 | physiological function |
Arabidopsis FC lyase recognizes amide-linked S-(2E,6E)-farnesyl-L-cysteine and may have a role in deprenylation of farnesylated proteins |
-, 710279 |
| 1.8.3.5 | metabolism |
apart from transporting lipids through the body, the human plasma lipoproteins very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) are also thought to serve as a modality for intra-organismal protein transfer, shipping proteins with important roles in inflammation and thrombosis from the site of synthesis to effector locations. Prenylcysteine oxidase 1, like dermcidin, cathelicidin antimicrobial peptide, TFPI-1 and fibrinogen alpha chain, is associated with both VLDL and LDL in human plasma. Analysis of VLDL- and LDL-associated proteins, overview |
743865 |
