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Results 1 - 7 of 7
EC Number
General Information
Commentary
Reference
malfunction
dysregulated extracellular renalase signalling promotes tumour growth
physiological function
administration of renalase lowers blood pressure and heart rate and also protects cells and organs against ischaemic and toxic injury. Independent of its enzymatic properties, renalase functions as a cytokine that provides protection to cells, tissues and organs by interacting with its receptor to activate protein kinase B, JAK/STAT, and the mitogen-activated protein kinase pathways. Extracellular renalase protects against renal injury, cardiac injury, and acute pancreatitis
physiological function
renalase degrades catecholamines contributing to blood pressure control
physiological function
renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure
physiological function
renalase knockout mouse model to explore the mechanisms mediating renalase's effect on phosphate excretion. Compared with wild-type mice maintained on a regular diet, knockout mice show decreased serum phosphate and increased urinary phosphate excretion. Both wild-type and knocout mice respond similarly to phosphate restriction by increasing renal catechol-O-methyl transferase COMT-1 activity and markedly decreasing phosphate excretion. Only catechol-O-methyl transferase expression and activity are significantly increased in knockout mice. Urinary dopamine increases by twofold, whereas urinary l-DOPA excretion decreases by twofold in the knockout mouse
physiological function
renalase participates in the pathophysiological mechanism of cardiac dysfunction by down-regulating the activity of sympathetic nervous system and degrading the level of catecholamines. Renalase is strongly associated with type 1 diabetes, hypertension and ischemic diseases
physiological function
renalase protects the cardiomyocytes of Sprague-Dawley rats against ischemia and reperfusion injury by reducing myocardial cell necrosis and apoptosis
Results 1 - 7 of 7