Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 11 > >>
EC Number
General Information
Commentary
Reference
malfunction
glycine encephalopathy (GCE) or nonketotic hyperglycinemia is an inborn error of glycine metabolism, inherited in an autosomal recessive manner due to a defect in any one of the four enzymes aminomethyltransferase (AMT), glycine decarboxylase (GLDC), glycine cleavage system protein-H (GCSH) and dehydrolipoamide dehydrogenase in the glycine cleavage system. This defect leads to glycine accumulation in body tissues, including the brain, and causes various neurological symptoms such as encephalopathy, hypotonia, apnea, intractable seizures and possible death. Mutations in both GLDC and AMT genes are the main cause of GCE in Malaysian population
metabolism
glycine decarboxylase is a major enzyme that is involved in the C1 metabolism of all organisms and in the photorespiratory pathway of plants and cyanobacteria. GCS is also essential in the plant photorespiratory C2 cycle, which salvages 2-phosphoglycolate resulting from the oxygenation reaction catalysed by ribulose-1,5-bisphosphate carboxylase/oxygenase under atmospheric conditions. The complete GCS reaction cycle requires the cooperation of three different enzymes, P-protein, T-protein and L-protein, and the small heat-stable H-protein, pathway overview
metabolism
the glycine decarboxylase complex, GDC, is a key enzyme of the photorespiratory C2 cycle in C3 plants, regulation of plant glycine decarboxylase by S-nitrosylation and glutathionylation, overview. GDC activity is inhibited by S-nitrosoglutathione due to S-nitrosylation/S-glutathionylation of several cysteine residues
more
glycine decarboxylase, or P-protein, is part of the glycine cleavage system, GCS
more
the mitochondrial photorespiratory system is involved in the regulation of NO signal transduction in Arabidopsis thaliana
physiological function
enzyme overexpression promotes glycolysis, serine/glycine metabolism, and the accumulation of pyrimidine nucleotides. Enzyme overexpression alone is able to transform NIH 3T3 cells in vitro and drive tumor formation in vivo
physiological function
glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. In humans, GLDC is part of a multienzyme complex (which includes the lipoyl-containing H-protein) that couples the decarboxylation of glycine to the biosynthesis of serine
physiological function
overexpression of the H-protein of glycine decarboxylase considerably enhances net-photosynthesis and growth of Arabidopsis thaliana. Glycine decarboxylase is an important feed-back signaller that contributes to the control of the Calvin-Benson cycle and hence carbon flow through both photosynthesis and photorespiration
physiological function
part of glycine cleavage system
physiological function
role of GDC in the harpin-induced plant defense response, overview
Results 1 - 10 of 11 > >>