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Results 1 - 10 of 16 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30evolution Aerobic bacteria and fungi typically express ATP- and NADPH-dependent enzymes, which were initially named aryl-aldehyde dehydrogenases (NADP+), but are meanwhile also mostly referred to as carboxylate reductases (CARs). These enzymes are classified as the EC 1.2.1.30 family. CAR sequences of the EC 1.2.1.30 family fall into four distinct subgroups -, 763290
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30evolution analysis of highly conserved signature sequences of CARs, overview -, 763083
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30evolution CAR phylogenetic analysis and tree -, 763297
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30malfunction lack of posttranslational phosphopantetheinylation of a serine group in the recombinant CAR reduces the activity of recombinantly expressed enzyme 763297
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30malfunction replacement of His237, Glu433, Ser595, Tyr844, and Lys848 by Ala abolishes CAR activity -, 763083
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30malfunction the purified CAR with a mutation to its conserved serine idue appears to degrade into separate A- and R-domains when incubated at room temperature 763297
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30more analysis of A-T-R domain architecture with relaxed substrate specificity, structure-function-relationship and potential as biocatalysts for organic synthesis, respectively. Identification of key residues for CAR activity -, 763290
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30more structure homology modeling -, 763083
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30more structure-function analysis and structure comparisons -, 763297
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.30physiological function carboxylic acid reductases (CARs) are valuable biocatalysts due to their ability to reduce a broad range of carboxylate substrates into the corresponding aldehyde products. CARs are multi-domain enzymes with separate catalytic domains for the adenylation and the subsequent reduction of substrates. Inter-domain dynamics are crucial for the catalytic activities of CARs -, 763295
Results 1 - 10 of 16 > >>