EC Number   |
General Information |
Reference  |
|---|
   1.14.99.38 | more |
Ch25h expression is controlled primarily by type I IFN signaling, type1 IFN-mediated Ch25h expression is IFNR-dependent, overview |
-, 715833 |
| 1.14.99.38 | physiological function |
cholesterol 25-hydroxylase plays an essential role in cholesterol metabolism in the body by catalysing the formation of 25-hydroxycholesterol from cholesterol which acts to repress cholesterol biosynthesis |
726545 |
| 1.14.99.38 | malfunction |
mice with a disruption in the cholesterol 25-hydroxylase gene regulate cholesterol metabolism normally. Ch25h-/- mice have higher levels of mRNAs coding for immunoglobulin A and immunoglobulin J. Disruption in the Cyp7b1 gene leads to significantly increased levels of 25-hydroxycholesterol in the circulation, and to significantly lower levels of IgA compared to wild-type mice |
727109 |
| 1.14.99.38 | malfunction |
patients with hereditary spastic paresis, a rare inherited disease with mutations in the CYP7B1 gene, have highly elevated levels of 25- and 27-hydroxycholesterol but normal levels of cholesterol and bile acids |
727109 |
| 1.14.99.38 | more |
25-hydroxycholesterol does not stimulate the sPLA2-IIA promoter in the mouse Schwann cell line MSC80 |
727109 |
| 1.14.99.38 | more |
the high concentrations of vitamin D3 metabolites required for upregulation of the cholesterol 25-hydroxylase gene makes it unlikely that these metabolites are important regulators of cholesterol 25-hydroxylase in vivo |
727109 |
| 1.14.99.38 | physiological function |
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol decreases the level of cytoplasmic IkBa and increases the nuclear NFkB level, its sulfated form has the opposite effects |
727109 |
| 1.14.99.38 | physiological function |
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol is, however, a weak activator of the liver X receptors. 25-Hydroxycholesterol is of great importance for maintaining cholesterol homeostasis. 25-Hydroxycholesterol induces the secretion of the proinflammatory cytokine IL-8 |
727109 |
| 1.14.99.38 | physiological function |
important role for 25-hydroxycholesterol in the immune system. High concentrations of 25-hydroxycholesterol induce apoptosis in a mouse oligodendrocyte cell line 158N in an liver X receptor-independent manner. Treatment of these cells with 25-hydroxycholesterol results in enhanced secreted phospholipase A2 activity |
727109 |
| 1.14.99.38 | malfunction |
loss of function of Ch25h leads to susceptibility to viral infections in vitro |
727611 |
