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Results 1 - 6 of 6
EC Number General Information Commentary Reference
Show all pathways known for 1.1.3.48Display the reaction diagram Show all sequences 1.1.3.48evolution the enzyme belongs to a putative distinct class of metal-dependent alcohol oxidases -, 734255
Show all pathways known for 1.1.3.48Display the reaction diagram Show all sequences 1.1.3.48malfunction creation of an Shewanella oneidensis kdnA/kdnB in-frame deletion strain shows increased sensitivity to the cationic antimicrobial peptide polymyxin as well as bile salts by 3fold and 2fold, respectively -, 734255
Show all pathways known for 1.1.3.48Display the reaction diagram Show all sequences 1.1.3.48metabolism 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis pathway, 8-dehydro-3-deoxy-D-manno-octulosonic acid is directly converted to Kdo8N followed by incorporation into lipid A, overview. The entire gene cluster is required for 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis -, 734255
Show all pathways known for 1.1.3.48Display the reaction diagram Show all sequences 1.1.3.48physiological function a KdnB knock-out strain shows 3fold increased sensitivity to polymyxin B and 2fold increased sensitivity to bile salts -, 734255
Show all pathways known for 1.1.3.48Display the reaction diagram Show all sequences 1.1.3.48physiological function endotoxin lipopolysaccharide is composed of a hydrophobic anchor, known as lipid A, an inner core oligosaccharide, and a repeating O-antigen polysaccharide. The first sugar bridging the hydrophobic lipid A and the polysaccharide domain is 3-deoxy-D-manno-octulosonic acid. Derivative 8-amino-3,8-dideoxy-Dmanno-octulosonic acid is found exclusively in marine bacteria of the genus Shewanella. Data are consistent with direct conversion of 3-deoxy-D-manno-octulosonic acid to 8-amino-3,8-dideoxy-D-manno-octulosonic acid prior to its incorporation into the 8-amino-3,8-dideoxy-D-manno-octulosonic acid-lipid A domain of lipopolysaccharide by a metal-dependent oxidase followed by a glutamate-dependent aminotransferase -, 734255
Show all pathways known for 1.1.3.48Display the reaction diagram Show all sequences 1.1.3.48physiological function the first sugar bridging the hydrophobic lipid A and the polysaccharide domain is 3-deoxy-D-manno-octulosonic acid (Kdo), and thus it is critically important for lipopolysaccharide biosynthesis -, 734255
Results 1 - 6 of 6