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physiological function
isoform 20beta-HSD type 2 is involved in cortisol catabolism and stress response. The morpholino-induced knock-down of gene expression in zebrafish embryos reveals no developmental phenotype under normal culture conditions, but prominent effects are observed after a cortisol challenge. 20beta-Hydroxycortisone is not a physiological ligand for the zebrafish glucocorticoid or mineralocorticoid receptor but is excreted into the fish holding water
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