EC Number   |
General Information |
Reference  |
|---|
   1.1.1.331 | metabolism |
the enzyme is involved in the lignan biosynthetic pathways in Forsythia, overview |
742033 |
| 1.1.1.331 | physiological function |
the enzyme SIRD is involved in the biosynthesis of lignan matairesinol in Forsythia. The leaves show seasonal alteration in amounts of major lignans, such as pinoresinol, matairesinol, and arctigenin, gene expression profile of secoisolariciresinol dehydrogenase (SIRD) and other related enzymes in the leaves of Forsythia suspense from April to November: all of the lignans in the leaf continuously increase from April to June, reach the maximal level in June, and then decrease |
742033 |
| 1.1.1.331 | metabolism |
the enzyme is part of the podophyllotoxin, PPT, biosynthetic pathway |
-, 743278 |
| 1.1.1.331 | more |
the enzyme forms a homotetramer composed of an alpha/beta single domain structure with a dinucleotide-binding Rossmann fold for the binding of NAD+ and an active site with a highly conserved catalytic triad of amino acids, Ser153, Tyr167 and Lys171 |
743278 |
| 1.1.1.331 | physiological function |
the enzyme secoisolariciresinol dehydrogenase facilitates the dehydrogenation of secoisolariciresinol to form matairesinol, a mid-pathway intermediate product in podophyllotoxin, PPT, biosynthesis |
-, 743278 |
| 1.1.1.331 | evolution |
molecular phylogenetic analysis of specialized metabolic enzyme genes from lignan-producing plants, two common gene clusters include genes from various plants and plant lineage-specific gene clusters. The specialized metabolic enzyme genes from lignan-producing plants include enzymes involved in the early common lignan biosynthesis upstream of matairesinol such as PLR and SIRD, suggesting that they have occurred in their ancestral plants and conserved their biological functions |
743611 |
| 1.1.1.331 | metabolism |
the enzyme is involved in the lignan biosynthesis pathway, overview |
743611 |
| 1.1.1.331 | physiological function |
matairesinol biosynthesis is prominently enhanced and matairesinol is highly accumulated in callus |
743611 |
| 1.1.1.331 | metabolism |
the enzyme is part of the podophyllotoxin, PPT, biosynthetic pathway, overview. Podophyllotoxin is an important aryltetralin lignan, that possesses antitumor and antihyperlipidemic activities |
743768 |
| 1.1.1.331 | metabolism |
the enzyme is involved in the enzymatic cascade for (-)-podophyllotoxin biosynthesis |
762561 |
