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EC Number
General Information
Commentary
Reference
metabolism
1-deoxy-D-xylulose-5-phosphate, DXP, reductoisomerase catalyzes the first committed step in the 2-C-methyl-D-erythritol 4-phosphate pathway involving a skeletal rearrangement of DXP via a retroaldol/aldol process followed by reduction by NADPH to yield 2-C-methyl-D-erythritol 4-phosphate
metabolism
the 1-deoxy-D-xylulose-5-phosphate reductoisomerase is the second enzyme in the nonmevalonate isoprene biosynthesis pathway, catalyzing the reductive isomerization of 1-deoxy-D-xylulose-5-phosphate to 2-methyl-D-erythritol-4-phosphate for making isopentenyl diphosphate and dimethylallyl diphosphate
metabolism
the enzyme catalyzes the second regulation step in the 2-C-methyl-D-erythritol 4-phosphate pathway and the the first committed step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis
metabolism
the enzyme is involved in a parasite-specific, isoprenoid biosynthetic DOXP/MEP pathway
metabolism
the enzyme is involved in the isoprenoid biosynthetic DOXP/MEP pathway
more
role of the nonreacting phosphorylmethyl group in catalysis, overview
more
two substrate-binding domains, LPADSEHSAI and NKGLEVIEAHY, locate in its mid-region of the enzyme molecule, which is highly homologous to DXRs from other plants and similar to the DXR from Escherichia coli
physiological function
1-deoxy-D-xylulose-5-phosphate reductoisomerase in the non-mevalonate isoprene biosynthesis pathway is essential to the organism
physiological function
a dxr gene T-DNA insertion mutant shows albino and dwarf phenotype. The mutant does not bolt, has a significantly reduced number of trichomes and most of the stomata cannot close normally in the leaves. Two transgenic co-suppression lines produce more yellow inflorescences and albino sepals with no trichomes. The transcription levels of genes involved in trichome initiation are strongly affected in the mutants. Exogenous application of gibberellic acid GA3 can partially rescue the dwarf phenotype and the trichome initiation of the insertion mutant, and exogenous application of abscisic acid can rescue the stomata closure defect
physiological function
in transgenic spike lavender plants (Lavandula latifolia) constitutively expressing the Arabidopsis thaliana DXR gene, a clear correlation between transcript accumulation and monoterpene production cannot be established. The DXR enzyme does not play a crucial role in the synthesis of plastidial monoterpene precursors
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