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Results 1 - 10 of 37 > >>
EC Number General Information Commentary Reference
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22evolution the enzyme belongs to the the UGDH family of proteins -, 739891
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22evolution the N- and C-terminal domains of UgdG share structural features with ancient mitochondrial ribonucleases named MAR. MARs are present in lower eukaryotic microorganisms, have a Rossmannoid-fold and belong to the isochorismatase superfamily -, 739981
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22malfunction Haloferax volcanii cells deleted of HVO_1531 present a modified S-layer -, 728319
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22malfunction mutant dimeric species of UGDH have reduced activity in vitro and in supporting hyaluronan production by cultured cells. The purified enzymes reveal a significant decrease in the enzymatic activity of the obligate dimer and hexamer mutants. Both T325A and T325D mutants were significantly less efficient in promoting downstream hyaluronan production by HEK293 cells 740715
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22malfunction UGDH protein level in rat osteoarthritis cartilage are much lower than the corresponding controls and negatively correlated to the degree of osteoarthritis -, 739967
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22malfunction UGDH specific siRNAs markedly inhibits UGDH mRNA and protein expression, and leads to an obvious suppression of proteoglycans synthesis in human articular chondrocytes. UGDH protein level in human osteoarthritis cartilage are much lower than the corresponding controls and negatively correlated to the degree of osteoarthritis. Interleukin-1beta inhibits UGDH gene expression through modulating UGDH transregulators and the downstream signaling cascades, including the SAP/JNK and p38 MAPK pathways which might be involved in the proteoglycans loss of osteoarthritis cartilage and contribute to the osteoarthritis pathogenesis 739967
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22metabolism enzyme displays a NAD+-dependent SN2 mechanism. The first oxidation involves the nucleophilic addition of the essential Cys residue. The acceptor of C6-OH of UDP-glucose is an ordered H2O molecule. The second NADH is released after hydrolysis of the thioester intermediate 761284
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22metabolism in the Haloferax volcanii archaeal glycosylation pathway, Agl, responsible for the assembly and attachment of an Asn-linked pentasaccharide, enzyme AglM acts as a UDP-glucose dehydrogenase, converting UDP-glucose into UDP-glucuronic acid -, 740935
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22metabolism the enzyme participates in sucrose/polysaccharide metabolism and cell wall biosynthesis 740128
Show all pathways known for 1.1.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.22more dysregulated expression of UGDH can promote the development of androgen independent tumor cell growth by increasing available levels of intracellular androgen. UGDH activity is the rate limiting factor in solubilization of excess androgen from prostate tumor cells, overview 711665
Results 1 - 10 of 37 > >>