EC Number   |
General Information |
Reference |
|---|
   6.3.4.10 | physiological function |
enzyme-dependent biotinylation of heat shock protein 72 increases expression of the chemokine regulated on activation normal T-expressed and presumably secreted by HEK-293 cells |
726655 |
| 6.3.4.10 | physiological function |
HCS catalyzes the binding of the vitamin biotin to carboxylases and histones |
705752 |
| 6.3.4.10 | physiological function |
HCS catalyzes transfer of biotin to biotin-dependent carboxylases, and the enzyme is therefore of fundamental importance for many physiological processes, including fatty acid synthesis, gluconeogenesis, and amino acid catabolism. In addition, the enzyme functions in regulating transcription initiation at several genes that code for proteins involved in biotin metabolism |
704561 |
| 6.3.4.10 | physiological function |
HCS co-localizes with histone H3 in human cells with physical interactions between HCS and H3. The N-terminal and C-terminal domains in HCS participate in H3 binding |
715997 |
| 6.3.4.10 | physiological function |
HCS is responsible for attaching biotin onto the biotin-dependent enzymes that reside in the cytoplasm and mitochondria |
701936 |
| 6.3.4.10 | physiological function |
HCS migrates to the nucleus at the gastrulation stage. In polytene chromosomes, it is associated to heterochromatin bands where it co-localizes with histone 3 trimethylated at lysine 9 but not with the euchromatin mark histone 3 acetylated at lysine 9. HCS associates with the hsp70 promoter. On heat-shock activation of the hsp70 promoter, HCS is displaced and the promoter region becomes enriched with the TFIIH subunits XPD and XPB and elongating RNA pol I |
716237 |
| 6.3.4.10 | physiological function |
identification of HCS docking sites in chromatin. 4 out of 15 docking sites overlap between MCF-7 and MCF-10A cells, i.e. inositol polyphosphate-5-phosphatase A, corticotropin hormone precursor, ribosome biogenesis regulatory protein, and leptin precursor |
713742 |
