EC Number   |
General Information |
Reference |
|---|
   4.6.1.18 | physiological function |
pancreatic ribonuclease is a digestive enzyme |
730952 |
| 4.6.1.18 | physiological function |
the enzyme has almost no anti-tumoral property in pancreatic adenocarcinoma cell lines and in nontumorigenic cells as normal control, and is largely ineffective as anti-proliferative and pro-apoptotic agent |
729310 |
| 4.6.1.18 | physiological function |
the enzyme has good anti-tumoral property in pancreatic adenocarcinoma cell lines and in nontumorigenic cells as normal control, it stimulates a strong anti-proliferative and pro-apoptotic effect in cancer cells. The enzyme triggers Beclin1-mediated autophagic cancer cell death, providing evidence that high proliferation rate of cancer cells may render them more susceptible to autophagy by treatment with the enzyme |
729310 |
| 4.6.1.18 | physiological function |
the human isozymes have evolved additional biological activities, often linked to innate host defense, neurotoxicity, angiogenesis, and immunosuppressive and/or antibacterial/antiviral activities |
729713 |
