EC Number   |
General Information |
Reference |
|---|
    4.1.1.11 | malfunction |
gene disruption of TK1814 results in a strain that cannot grow in standard medium. Addition of beta-alanine, 4'-phosphopantothenate, or CoA complements the growth defect, whereas gamma-aminobutyrate (GABA) cannot complement |
-, 748086 |
| 4.1.1.11 | malfunction |
protein PanZ is essential for activation of the zymogen PanD to form ADC in vivo, and its deletion leads to beta-alanine auxotrophy |
747497 |
| 4.1.1.11 | malfunction |
the Glu56Ser mutation improves the enzymatic activity and catalytic stability of L-aspartate alpha-decarboxylase for an efficient beta-alanine production. The E56S mutant shows an approximately 1.4fold increased residual activity compared with the wild-type during 2 h reaction at 37°C, suggesting that the E56S mutation attenuated the mechanism-based inactivation of the enzyme |
-, 749207 |
| 4.1.1.11 | malfunction |
when expressed in the Salmonella enterica DELTApanM strain, all panD homologues from bacteria that also contain a panM gene (Salmonella enterica, Klebsiella pneumoniae, Pseudomonas aeruginosa) fail to restore growth on minimal medium |
-, 747435 |
| 4.1.1.11 | metabolism |
enzyme PanD is responsible for the production of beta-alanine in the pantothenate biosynthesis pathway. The production of beta-alanine is feedback-regulated by the PanZ-AcCoA complex |
747128 |
| 4.1.1.11 | metabolism |
L-aspartate alpha-decarboxylase catalyzes the conversion of aspartate to beta-alanine in the pantothenate pathway, which is critical for the growth of Mycobacterium tuberculosis |
728571 |
| 4.1.1.11 | metabolism |
the enzyme catalyzes the first step in the biosynthetic pathway of pantothenate and coenzyme A, overview |
-, 728266 |
| 4.1.1.11 | metabolism |
the enzyme catalyzes the first step in the biosynthetic pathway of pantothenate and coenzyme A, pathway overview |
726592 |
| 4.1.1.11 | metabolism |
the enzyme is involved in the melanin metabolism pathway and in the melanin metabolism from dopamine to N-beta-alanyl dopamine (NBAD) |
749304 |
| 4.1.1.11 | metabolism |
the structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A, regulatory model whereby the mature enzyme activity is limited and regulated by the concentration of CoA in the cell. Inhibition of mature enzyme catalysis reveals a second global role for PanZ in regulation of pantothenate biosynthesis. Such inhibitory activity is actually the primary metabolic role of PanZ, although the activation is also clearly essential |
747497 |
