EC Number   |
General Information |
Reference |
|---|
   3.4.21.7 | more |
released from CORM-2 and nitric oxide via a NO donor to induce carboxyheme and metheme states, respectively. CO elicits hypofibrinolysis by enhancing alpha2-antiplasmin activity and decreasing plasmin activity |
717417 |
| 3.4.21.7 | more |
the catalytic triad is formed by His603, Asp646, and Ser741 |
717469 |
| 3.4.21.7 | physiological function |
application of plasmin to primary neurons blocks isoflurane-mediated reduction in dendritic filopodial spines and neuronal apoptosis in vitro |
707135 |
| 3.4.21.7 | physiological function |
contribution of plasmin to amplification of inflammation in patients with psoriasis. Annexin II, a receptor for plasmin is dramatically increased in both dermis and epidermis in psoriasis. Plasmin at sites of inflammation is pro-inflammatory, eliciting production of inflammatory factors, including CC chemokine ligand 20 and interleukin-23, that is mediated by the nuclear factor-kappaB (NF-kB) signaling pathway and that has an essential role in the recruitment and activation of pathogenic C-C chemokine receptor type 6+ T cells |
718272 |
| 3.4.21.7 | physiological function |
inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura, propagation by deficiency of alpha2-antiplasmin function in acute-phase, but not remission-phase plasma, overview. ADAMTS13 is truncated at the C-terminus during the acute phase |
718043 |
| 3.4.21.7 | physiological function |
microglia-derived plasminogen/plasmin facilitate the production/secretion of TGFbeta3 in astrocytes through both proteinase-activated receptor-1 and the downstream phosphatidylinositol 3-kinase-Akt/protein kinase B signaling cascade |
707930 |
| 3.4.21.7 | physiological function |
plasmin and urokinase-type plasminogen activator are ubiquitous proteases that regulate the extracellular environment. Although neither plasmin nor urokinase-type plasminogen activator exhibits allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition |
717386 |
| 3.4.21.7 | physiological function |
plasmin cleavage of inactive complement component C3b regulates macrophage interleukin-12 secretion |
732405 |
| 3.4.21.7 | physiological function |
plasmin is essential in preventing periodontitis in mice |
717069 |
| 3.4.21.7 | physiological function |
plasmin is the principal protease in milk. Plasmin, but not cathepsin D, cleavage of osteopontin increases cell adhesion mediated by the alphaVbeta3- or alpha5beta1-integrins. Similar cellular adhesion is mediated by plasmin and thrombin-cleaved osteopontin, plasmin can be a potent regulator of osteopontin activity |
712488 |
