EC Number   |
General Information |
Reference |
|---|
   3.4.21.46 | physiological function |
mature factor D is required for the alternative complement pathway |
732272 |
| 3.4.21.46 | physiological function |
PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling |
707940 |
| 3.4.21.46 | physiological function |
serum VEGF-D levels are greater in patients with lympangioleiomyomatosis with lymphatic involvement |
708131 |
| 3.4.21.46 | physiological function |
targeting of the enzyme's exosite causes inhibition of the pathway complement activation |
732044 |
| 3.4.21.46 | physiological function |
the enzyme is involved in immune responses in rock bream. The enzyme is vital to alternative complement pathway activation in cleaving complement factor B. This catalytic reaction forms the alternative C3 convertase that is crucial for complement-mediated pathogenesis |
753602 |
| 3.4.21.46 | physiological function |
the enzyme protects mice from ethanol-induced inflammation and liver injury. The enzyme contributes to the maintenance of tissue homeostasis during chronic ethanol by facilitating the clearance of apoptotic cells |
752442 |
| 3.4.21.46 | physiological function |
the enzyme shows antimicrobial activity against both gram-positive bacteria like Staphylococcus aureus and gram-negative bacteria like Aeromonas hydrophila |
753616 |
| 3.4.21.46 | physiological function |
treatment of young fibroblasts with complement factor D results in increased matrix metalloproteinase 1 gene expression |
752876 |
