EC Number   |
General Information |
Reference |
|---|
   3.4.21.27 | malfunction |
patients who have a very severe FXI deficiency are prone to development of inhibitor antibodies. During major surgeries, a single low dose of recombinant activated factor VII and tranexamic acid secure normal haemostasis in patients with severe FXI deficiency who can not receive blood products |
710600 |
| 3.4.21.27 | malfunction |
probably due to inbreeding, presence of FXI deficiency |
709722 |
| 3.4.21.27 | physiological function |
78% homology to human FXI at the protein level. FXI is critical for fibrin formation in vivo. FXI may have additional functions in regulation of inflammation or tissue repair distinct from its role in coagulation |
709722 |
| 3.4.21.27 | physiological function |
activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor |
731538 |
| 3.4.21.27 | physiological function |
activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. Coagulation factor XI participates in the intrinsic coagulation pathway upon its activation, contributing to hemostasis and thrombosis. Factor XIa attenuates N-formylmethionyl-leucyl-phenylalanine-induced Ca2+mobilization |
717958 |
| 3.4.21.27 | physiological function |
coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1 |
752439 |
| 3.4.21.27 | physiological function |
factor XI is important in the tissue factor-independent propagation phase of clot formation, not in the initiation process |
731773 |
| 3.4.21.27 | physiological function |
factor XIa plays its major role in promoting late thrombin formation (i.e. the thrombin required for thrombin activatable fibrinolysis inhibitor-mediated inhibition of fibrinolysis) |
718045 |
| 3.4.21.27 | physiological function |
FXI is a biomarker with increased levels reported as a risk factor for venous thromboembolism and myocardial ischemia or stroke |
707308 |
| 3.4.21.27 | physiological function |
FXI is the zymogen of a blood coagulation protease, factor XIa (activated factor IX), that contributes to hemostasis through activation of factor IX. Almost all FXI circulate in a complex with kininogen |
707856 |
