EC Number   |
General Information |
Reference |
|---|
  2.1.1.182 | physiological function |
knockout of KsgA attenuates the killing ability against silkworms. The KsgA knockout strain is sensitive to oxidative stress and has a lower survival rate in murine macrophages than the parent strain. The KsgA knockout strain exhibits decreased translational fidelity in oxidative stress conditions. Administration of N-acetyl-L-cysteine restores the killing ability of the knockout strain against silkworms |
-, 756118 |
| 2.1.1.182 | physiological function |
KsgA acts as a ribosome biogenesis factor. KsgA alters 16S rRNA processing and has a critical role is as a supervisor of biogenesis of 30S subunits in vivo |
705774 |
| 2.1.1.182 | physiological function |
KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness |
-, 702903 |
| 2.1.1.182 | physiological function |
KsgA has a DNA glycosylase/AP lyase activity for C mispaired with oxidized T that prevents the formation of mutations, which is in addition to its rRNA adenine methyltransferase activity essential for ribosome biogenesis |
705968 |
| 2.1.1.182 | physiological function |
KsgA, in addition to its methyltransferase activity, has another unidentified function that plays a role in the suppression of the cold-sensitive phenotype of the Era(E200K) strain. The additional function may be involved in the acid shock response |
704274 |
| 2.1.1.182 | physiological function |
the enzyme contributes to maintain ribosome function under oxidative conditions and thus to Staphylococcus aureus virulence |
-, 733426 |
| 2.1.1.182 | physiological function |
the enzyme plays a role in intrinsic clarithromycin resistance and ribosome biogenesis in Mycobacterium tuberculosis |
-, 733980 |
| 2.1.1.182 | physiological function |
the KsgA methyltransferase is universally conserved and plays a key role in regulating ribosome biogenesis. KsgA has a complex reaction mechanism, transferring a total of four methyl groups onto two separate adenosine residues, A1518 and A1519, in the small subunit rRNA. This means that the active site pocket must accept both adenosine and N6-methyladenosine as substrates to catalyze formation of the final product N6,N6-dimethyladenosine |
718932 |
