EC Number   |
General Information |
Reference |
|---|
   2.1.1.179 | physiological function |
the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview |
-, 719353 |
| 2.1.1.179 | physiological function |
the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Pseudomonas aeruginosa clinical isolates show high-level resistance to clinically useful aminoglycosides through the production of acquired 16S-RMTase. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview |
719353 |
| 2.1.1.179 | physiological function |
the enzyme confers high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA. RmtC impedes methylation by the housekeeping methyltransferase RsmF, EC 2.1.1.178, at position C1407 |
-, 718596 |
| 2.1.1.179 | physiological function |
the enzyme confers high-level resistance to aminoglycosides |
-, 735238 |
| 2.1.1.179 | physiological function |
the enzyme gives resistance to kanamycin plus gentamicin by converting guanine1405 to 7-methylguanine |
705105 |
| 2.1.1.179 | physiological function |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
705972 |
