EC Number   |
General Information |
Reference |
|---|
   2.1.1.179 | more |
Kmr shows intrinsic N7-G1405 16S-RMTase activity |
719353 |
| 2.1.1.179 | more |
NbrB shows intrinsic N7-G1405 16S-RMTase activity |
719353 |
| 2.1.1.179 | more |
Sgm shows intrinsic N7-G1405 16S-RMTase activity |
719353 |
| 2.1.1.179 | more |
Smr1 shows intrinsic N7-G1405 16S-RMTase activity |
719353 |
| 2.1.1.179 | physiological function |
encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides. The expression of the sgm gene is regulated by the translational autorepression |
704254 |
| 2.1.1.179 | physiological function |
G1405 methylation produces aminoglycoside resistance by diminishing the affinity of the ribosome for gentamicin |
712738 |
| 2.1.1.179 | physiological function |
methylation of C1405, involved in the binding of aminoglycosides to 16S rRNA, can lead to loss of affinity and to resistance of the host. Resistance conferred by RmtF cannot be transferred to Escherichia coli via transfer of plasmid pIP849 |
-, 718603 |
| 2.1.1.179 | physiological function |
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis, These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview |
719353 |
| 2.1.1.179 | physiological function |
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview |
719353 |
| 2.1.1.179 | physiological function |
rmtC is responsible for resistance of strain ARS68 and its transformant to various aminoglycoside antibiotics |
-, 710880 |
