EC Number   |
General Information |
Reference |
|---|
   1.4.4.2 | physiological function |
glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. In humans, GLDC is part of a multienzyme complex (which includes the lipoyl-containing H-protein) that couples the decarboxylation of glycine to the biosynthesis of serine |
741906 |
| 1.4.4.2 | physiological function |
key enzyme in the glycine cleavage system that regulates glycolysis and methylglyoxal production in cancer |
765323 |
| 1.4.4.2 | physiological function |
overexpression of the H-protein of glycine decarboxylase considerably enhances net-photosynthesis and growth of Arabidopsis thaliana. Glycine decarboxylase is an important feed-back signaller that contributes to the control of the Calvin-Benson cycle and hence carbon flow through both photosynthesis and photorespiration |
725016 |
| 1.4.4.2 | physiological function |
part of glycine cleavage system |
706478 |
| 1.4.4.2 | physiological function |
role of GDC in the harpin-induced plant defense response, overview |
713311 |
| 1.4.4.2 | physiological function |
the enzyme catalyzes the first and rate-limiting step in glycine breakdown with the production of the one-carbon unit 5,10-methylene-tetrahydrofolate. Critical role of the enzyme (GLDC) in sustaining the proliferation of neuroblastoma cells with high-level GLDC expression |
765486 |
| 1.4.4.2 | physiological function |
the enzyme promotes tumor initiation and proliferation in non-small cell lung cancer and glioma and it is a putative tumor suppressor gene in gastric cancer. Knockdown of the enzyme (GLDC) enhances cancer cell migration and invasion, GLDC overexpression inhibits them. GLDC downregulation decreases ROS-mediated ubiquitination of cofilin to enhance hepatocellular carcinoma progression and intrahepatic metastasis |
764702 |
| 1.4.4.2 | physiological function |
the H-protein interacts with the L-protein, which is also part of the L-ketoglutarate dehydrogenase complex |
724197 |
