EC Number   |
General Information |
Reference |
|---|
    1.1.1.22 | physiological function |
in breast cancer cells, depletion of the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhibit several mesenchymal-like properties including cellular invasion and colony formation in vitro, as well as tumor growth and metastasis in vivo. Depletion of UDP-glucuronic acid alters the expression of PPAR-gamma target genes and increases PPAR-gamma DNA binding activity |
762065 |
| 1.1.1.22 | physiological function |
in Escherichia coli K-12, Ugd is important for biosynthesis of the environmentally regulated exopolysaccharide known as colanic acid, whereas in other Escherichia coli isolates, the same enzyme is required for production of the constitutive group 1 capsular polysaccharides, which act as virulence determinants |
740710 |
| 1.1.1.22 | physiological function |
in Escherichia coli serotype K30, the enzyme is required for production of the constitutive group 1 capsular polysaccharides, which act as virulence determinants |
740710 |
| 1.1.1.22 | physiological function |
knocking out UGDH in highly metastatic 6DT-1 breast cancer cells impairs migration ability without affecting in vitro proliferation. UGDH-KO results in significantly decreased metastatic capacity in vivo when the cells are orthotopically injected in syngeneic mice |
760809 |
| 1.1.1.22 | physiological function |
precise allelic exchange mutagenesis of isoform hasB in strain 5448, a representative of the globally disseminated M1T1 serotype, does not abolish hyaluronic acid capsule synthesis due to presence of paralog HasB2. Mutagenesis of HasB2 alone slightly decreases capsule abundance. A HasB HasB2 double mutant becomes completely acapsular |
-, 725276 |
| 1.1.1.22 | physiological function |
the ectopic overexpression of UGDH4 in Arabidopsis thaliana significantly increases the contents of hemicellulose and soluble sugar |
762397 |
| 1.1.1.22 | physiological function |
the enzme synthesize UDP-glucuronate, a key sugar nucleotide involved in biosynthesis of the plant cell wall, the LgUGDH gene plays a role in controlling the biosynthesis of secondary cell walls |
740128 |
| 1.1.1.22 | physiological function |
the enzyme is involved in protein N-glycosylation |
-, 728319 |
| 1.1.1.22 | physiological function |
the enzyme is involved in the biosnthesis of the Ss sphingan biopolymer |
-, 739891 |
| 1.1.1.22 | physiological function |
the enzyme provides UDP-glucuronic acid for the synthesis of the exopolysaccharide gellan |
-, 739981 |
