EC Number   |
General Information |
Reference  |
|---|
   3.4.21.78 | metabolism |
CD8 T cells in psoriasis skinlesions display a dominant expression of granzyme A (GzmA) over granzyme B in the absence of perforin expression. Signals recruiting GzmA+ T cells into the skin and triggers of GzmA expression in the context of chronic inflammation, Tc17-polarizing conditions favour development of GzmA+GzmB-Prf-CD8 T-cells in the context of psoriasis |
753512 |
| 3.4.21.78 | physiological function |
interleukin-17 induced secretion of the cytokines interleukin-6, interleukin-8 and interleukin-23, whereas GzmA treatment alone does not induce secretion of inflammatory mediators. The combination of GzmA and interleukin-17 significantly increases the release of the proinflammatory chemokines CXCL 1, CXCL 12, and CCL 4 compared to interleukin-17 stimulation alone, but does not alter the levels of interleukin-17-induced cytokines interleukin-6, interleukin-8 and interleukin-23. GzmA neither promotes proliferation nor affects interleukin-17-induced keratinocyte differentiation status as measured by gene expression of MKI67, IVL, KRT16 or KRT10 |
753512 |
| 3.4.21.78 | malfunction |
phenotypic characterization of gzmA-/- regulatory T cells (Tregs) efficiently homing to secondary lymphoid organs, GzmA-/- Tregs home efficiently to secondary lymphoid organs, overview. No difference between wild-type and GZMA-/- mice in Treg numbers in spleen and peripheral lymph nodes. Enzyme-deficient gzmA-/- Tregs cannot efficiently protect from GvHD-related inflammation and organ destruction in the intestinal tract with relevant crypt apoptosis detected in the small and large intestine |
755083 |
| 3.4.21.78 | physiological function |
granzyme A is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease. Analysis of the role of granzyme A (GZMA) in a haploidentical murine graft-versus-host disease (GvHD) model using gzmA-/- donor regulatory T cells (Tregs) to clarify the functional relevance of GZMA for Treg-mediated suppression of GvHD. GZMA expressing Tregs protect against GvHD-related tissue damage of the intestine |
755083 |
| 3.4.21.78 | malfunction |
even though granzyme A is expressed by cytotoxic cells from mouse lungs during pulmonary infection, its deficiency in knockout mice does not have an effect in the control of Mycobacterium tuberculosis infection |
-, 755118 |
| 3.4.21.78 | physiological function |
granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis strain H37Rv infection but does not contribute to protection in vivo. Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis |
-, 755118 |
| 3.4.21.78 | physiological function |
high functional activity of GzmA in the innate cell-mediated cytotoxicity |
771416 |
| 3.4.21.78 | physiological function |
the enzyme is an extracellular modulator of inflammation. The presence and role of extracellular granzyme A (GrA) in several inflammatory diseases and the potential molecular mechanisms of extracellular GrA in augmenting inflammation is summarized |
771430 |
| 3.4.21.78 | physiological function |
granzyme A from cytotoxic lymphocytes cleaves gasdermin B to trigger pyroptosis in target cells. This immune effector mechanism promotes cytotoxic T lymphocyte-mediated tumor clearance in mice |
776005 |
