EC Number   |
General Information |
Reference |
|---|
   3.1.3.56 | malfunction |
mutations in INPP5K have been detected in patients with a rare form of autosomal recessive congenital muscular dystrophy with cataract, short stature and intellectual disability |
768412 |
| 3.1.3.56 | physiological function |
mutations of the isoform SHIP2 result in defects in insulin signaling and obesity |
730981 |
| 3.1.3.56 | evolution |
phylogenetic analyses are performed to delineate the evolutionary history of the polyphosphate 5-phosphatase family in major angiosperm lineages |
771726 |
| 3.1.3.56 | physiological function |
pollen dormancy and germination |
772168 |
| 3.1.3.56 | physiological function |
SHIP2 plays a role in negative regulation of insulin signaling and as a potential drug target for obesity and type 2 diabetes |
730984 |
| 3.1.3.56 | physiological function |
the enzyme has essential functions in growth, development, and stress responses in plants, yeasts, and animals |
771726 |
| 3.1.3.56 | physiological function |
the enzyme is crucial for maintaining pollen dormancy |
729621 |
| 3.1.3.56 | physiological function |
the enzyme is involved in plant growth and abiotic stress responses. Le5PT1 may have a negative role in response to water deficit through the repression of drought-inducible genes that in turn affects plant growth and development |
-, 768111 |
| 3.1.3.56 | physiological function |
the enzyme links endoplasmic reticulum stress to insulin resistance in skeletal muscle |
751561 |
| 3.1.3.56 | malfunction |
the increase in the levels of 1D-myo-inositol 1,4,5-trisphosphate/Ca2+ caused by deficiency of inositol polyphosphate 5-phosphatases is sufficient to break pollen dormancy and to trigger early germination |
729621 |
