EC Number   |
Expression |
Reference |
|---|
    6.3.4.5 | down |
in the kidney, there is a significant decrease in ass mRNA expression level after 6 months of aestivation. In skeletal muscle, Ass mRNA expression decreases during aestivation |
745449 |
| 6.3.4.5 | down |
L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis |
745767 |
| 6.3.4.5 | down |
tumoural enzyme downregulation by hepatocellular carcinoma, malignant melanoma, malignant pleural mesothelioma, prostate and renal cancer |
704078 |
| 6.3.4.5 | more |
downregulation of enzyme expression is associated with the development of platinum resistance to platinum-based drugs |
704070 |
| 6.3.4.5 | more |
hepatic argininosuccinate synthase expression is hormonally regulated, expression of endothelial and inflammatory cell argininosuccinate synthase is under control of cytokines |
704078 |
| 6.3.4.5 | more |
in the brain, changes in Ass and asl mRNA expression levels during the three phases of aestivation can be related to the supply of arginine for NO synthesis in response to conditions that resemble ischaemia and ischaemia-reperfusion during the maintenance and arousal phase of aestivation, respectively |
745449 |
| 6.3.4.5 | more |
threefold repression of enzyme formation by arginine |
-, 725629 |
| 6.3.4.5 | up |
argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1 |
746432 |
| 6.3.4.5 | up |
Ass1 expression is upregulated significantly at implantation site on day 5 of pregnancy. Ass1 expression is induced by cAMP through PKA/p-Creb signaling pathway |
745767 |
| 6.3.4.5 | up |
gene expression is upregulated in primary human colorectal tumors |
743919 |
