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EC Number Expression Commentary Reference
Show all pathways known for 6.3.4.16Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.16down human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells 713715
Show all pathways known for 6.3.4.16Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.16more nutrient depletion does not increase CPS1 protein levels in wild-type or KO cells 703149
Show all pathways known for 6.3.4.16Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.16up nobiletin is able to lower serum ammonia levels in mice fed with regular chow (RC), high-fat (HFD) or high-protein diet. NOB rescues CPS1 protein levels under the HFD condition via induction of the transcription factors C/EBPalpha and C/EBPbeta. HPD markedly increases CPS1 levels relative to RC. A functional circadian clock, is required for nobiletin induction of CPS1 under the HFD condition 745931
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