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EC Number
Expression
Commentary
Reference
3.5.4.16
up
Dube3a has a co-transcriptional activation function for GCH1
720551
3.5.4.16
up
Dube3a has a co-transcriptional activation function for GCH1. Punch protein isoform B levels change as a result of Dube3a overexpression or loss of function in the fly brain
720551
3.5.4.16
up
exposure to the NO donor spermine NONOate (0-0.1 mM) leads to an dose-dependent increase in GCH1 protein. GCH1 promoter activity is enhanced by spermine NONOate in a CREB-dependent manner
710818
3.5.4.16
up
tetracycline stimulation substantially increases GCH-1 activity about 20fold
711068
3.5.4.16
up
the autoinhibitory peptide provides a molecular mechanism for physiological up-regulation of GTPCH activity
719914
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