EC Number |
Expression |
Reference |
---|
3.4.24.B12 | down |
fibroblast growth factor 2 inhibits ADAMTS-5 expression in isolated aortic smooth muscle cells and blocks the spontaneous release of ADAMTS-generated versican and aggrecan fragments from aortic explants |
734180 |
3.4.24.B12 | down |
the enzyme is expressed 2.1fold less in Sertoli cells of individuals with nonobstructive azoospermia than those of control individuals with obstructive azoospermia |
755570 |
3.4.24.B12 | more |
ADAMTS-5 expression is not regulated by interleukin-1 and tumor necrosis factor-alpha |
720093 |
3.4.24.B12 | up |
Adamts5 mRNA is superinduced in Fgf2/ mice compared with Fgf2+/+ (fibroblast growth factor 2) mice 2 weeks following surgical destabilization of the medial meniscus |
707317 |
3.4.24.B12 | up |
ADAMTS5 protein within cartilage increases following injury and with coculture |
707277 |
3.4.24.B12 | up |
disruption of chondrocyte hyaluran receptor CD44-hyaluran interactions with hyaluran oligosaccharides induces the transcription of endopeptidases ADAMTS-4 and ADAMTS-5 in a time- and dose-dependent manner |
733229 |
3.4.24.B12 | up |
interleukin-1beta+OSM and tumor necrosis factor alpha+ OSM treatments induces a 17fold and 13fold increase in ADAMTS5 gene expression. Relatively little modulation in ADAMTS5 expression is observed in the presence of interleukin-1beta, tumor necrosis factor alpha or OSM alone |
719385 |