EC Number   |
Expression |
Reference |
|---|
   3.4.24.79 | down |
enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome. interferon-gamma decreases enzyme expression in human fibroblasts |
735323 |
| 3.4.24.79 | down |
enzyme expression significantly decreases with age in bone and skeletal muscle |
753513 |
| 3.4.24.79 | up |
after intravenous unfractionated heparin and low molecular weight heparin free PAPP-A increases significantly (85 to 310fold from baseline) |
719309 |
| 3.4.24.79 | up |
enzyme blood plasma levels are elevated in patients with acute coronary syndrome |
754523 |
| 3.4.24.79 | up |
enzyme expression in cultured human dermal fibroblasts, human coronary artery endothelial, osteoblasts, and smooth muscle cells is stimulated by tumor necrosis factor-alpha, interleukin-1beta, interleukin-4, and transforming growth factor-beta. Enzyme expression is upregulated in response to acute injury. Gene expression is induced by forskolin and prostaglandin E2 in human osteoblasts, by bone morphogenic protein-2 in human mesenchymal stem cells, and by follicle-stimulating hormone in bovine granulosa cells in culture |
735323 |
| 3.4.24.79 | up |
enzyme expression significantly increases with age in kidney, brain and gonads |
753513 |
| 3.4.24.79 | up |
injection of heparin (5000 IU) elicits increase in enzyme concentrations |
733672 |
| 3.4.24.79 | up |
the concentration of enzyme antigen in follicular fluid increases upon stimulation of ovulation with human chorionic gonadotrophin, but at the same time the enzyme activity is decreased |
753775 |
